7/4/2023 0 Comments Feedy slavkoSlavko Perović (Serbian Cyrillic: Славко Перовић born 9 June 1989 in Kragujevac) is a Serbian footballer who plays as a striker for Liga I club Dinamo București. Slavko Vučković (Serbian Cyrillic: Cлaвкo Bучкoвић, born 5 August 1982) is a Serbian footballer who plays for Ararat Yerevan. Slavko Matić (Serbian Cyrillic: Славко Матић, born 2 July 1976) is a Serbian football manager and former player. Slavko Goluža (born 17 September 1971) is a Croatian professional handball coach and former player. Slavko Vraneš ( pronounced born January 30, 1983) is a Montenegrin former professional basketball player. Asterisks indicate a significant difference (* p < 0.05) from respective controls as determined by Student’s t test.Famous people with name Slavko (Namesakes) Two representative animals from vehicle (Ctr) or ikemagenin (Ike)-treated groups are shown. (D) The hypothalamic AgRP protein level decreased following a single oral dose of 10 mg/kg ikemagenin as measured by Western blot analysis and was quantified densitometrically using GAPDH as a loading control. (C) Hypothalamic mRNA expression of anorexic (POMC, CART, and BDNF) and orexigenic (AgRP and NPY) central satiety peptides in male rats ( n = 4) treated with vehicle (Ctr) or a single oral dose of 10 mg/kg ikemagenin (Ike). (B) Daily food intake of male rats ( n = 4) receiving a single oral dose of 10 mg/kg ikemagenin. (A) Chemical structure of ikemagenin showing four saccharide moieties attached at the C3 position including oleandrose (Ole), digitoxose (Dig), and cymarose (Cym). Asterisks indicate a significant difference (* p < 0.05, and ** p < 0.01) from respective controls as determined by one-way ANOVA and Dunnett’s post-test.Įffect of a pregnane glycoside (ikemagenin) on food intake and levels of central satiety peptides in the hypothalamus. (E) Daily food intake of male rats ( n = 4) orally administered with vehicle (Ctr) or incarnatin fractions of high (A), middle (B), and low (C) polarity. (D) Gastric accommodation of male rats ( n = 6) 1 h after receiving a single dose of 50 or 100 mg/kg incarnatin. (C) Fasting-induced food intake of male rats ( n = 6) after a single dose of 50 or 100 mg/kg incarnatin during 0–3, 3–6, and 0–24 h time periods following the dosing. (B) Daily food intake of male rats ( n = 6) orally administered with vehicle (Ctr) or 20, 50, and 100 mg/kg/day of incarnatin during five dosing days (gray box) and three recovery days. (A) Chromatogram of incarnatin extract at 254 nm with (−)ESI LC-MS fragmentation of ikemagenin shown in the inset. incarnata root extract enriched with pregnane glycosides (incarnatin) on food intake in rats. These results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of the melanocortin signaling pathway and BDNF.Įffect of A. Ikemagenin treatment also increased secretion of brain-derived neurotropic factor (BDNF) downstream of melanocortin receptors in the hypothalamus (1.4-fold) and in the C6 rat glioma cell culture in vitro (up to 6-fold). The major milkweed pregnane glycoside, ikemagenin, exerted its appetite-regulating effect by decreasing levels of agouti-related protein (0.6-fold) but not NPY satiety peptides. Here, we show that pregnane glycoside-enriched extracts from swamp milkweed Asclepias incarnata at 25-100 mg/kg daily attenuated food intake (up to 47.1 ± 8.5% less than controls) and body weight gain in rats (10% for males and 9% for females, respectively) by activating melanocortin signaling and inhibiting gastric emptying. Pregnane glycosides appear to modulate food intake by possibly affecting the hypothalamic feeding circuits however, the mechanisms of the appetite-regulating effect of pregnane glycosides remain obscure.
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